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  1. Example 28 N 1S, 2S 2 methoxycyclobutyl 6 1 3R, 4S 4 methoxytetrahydrofuran 3 yl 1H pyrrolo 2, 3 b pyridin 3 yl 8 methylamino imidazo 1, 2 b pyridazine 3 carboxamide I 48 N 1R, 2R 2 methoxycyclobutyl 6 1 3R, 4S 4 methoxytetrahydrofuran 3 yl 1H pyrrolo 2, 3 b pyridin 3 yl 8 methylamino imidazo 1, 2 b pyridazine 3 carboxamide I 49 natural alternatives to tamoxifen

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